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Strengthening TB Pharmaceutical Management in Region IV-A Through Partnership and Capacity Building

In the Philippines, tuberculosis (TB) is the sixth leading cause of death, mostly affecting the poor and vulnerable populations. Stock-outs of TB medicines in public health facilities compromise treatment of patients with TB because of limited access and additional burden of out-of-pocket expenses for medicines. As part of the improvement of the overall supply chain of the TB program, SIAPS has been working with the Department of Health central office with focus on quantification, procurement, storage, distribution, and pharmacovigilance. In addition, the National TB Control Program (NTP) requested SIAPS to develop an action-oriented practical guide for TB pharmaceutical management.

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Implementing an TB/HIV Active Surveillance System in Swaziland

SIAPS supported the Swaziland Ministry of Health (MOH) in mobilizing key stakeholders from the Swaziland National AIDS Program and the National Tuberculosis Control Program to introduce and implement an active surveillance system for patients on ARVs and anti-TB treatment. SIAPS provided technical assistance to MOH’s National Pharmacovigilance Unit (NPVU) to develop the protocol and tools to implement the system, as well as to develop a system for recruiting patients at the HIV and TB sites.

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The Economic Cost of Non-Adherence to TB Medicines Resulting from Stock-Outs and Loss to Follow-Up in the Philippines

A key element of successful tuberculosis (TB) control programs is adherence to treatment. Non-adherence results in increased length and severity of illness, death, disease transmission, and drug resistance. The purpose of this study was to estimate the morbidity and mortality impact and economic costs of non-adherence to TB medicines resulting from treatment interruption due to stock-outs or loss to follow-up (LTFU).

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The Economic Cost of Non-adherence to TB Medicines Resulting from Stock-outs and Loss to Follow-up in Kenya – Research Summary

One of the key elements of successful tuberculosis (TB) control programs is adherence to treatment, which is a cornerstone of most international and national policies and guidelines. Non-adherence results in increased length and severity of illness, death, disease transmission, and drug resistance. Treatment interruption is often due to patient-related factors—classed as loss to follow-up (LTFU)—but can also be a result of provider issues, such as stock-outs of medicines. The purpose of this study was to estimate the morbidity, mortality, and economic impact of TB treatment interruption due to stock-outs and LTFU. The results are expected to help promote the benefits of ensuring the availability of good quality medicines and of undertaking interventions to reduce LTFU.

For the full report, please follow this link.

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The Economic Cost of Non-adherence to TB Medicines Resulting from Stock-outs and Loss to Follow-up in Kenya

One of the key elements of successful tuberculosis (TB) control programs is adherence to treatment, which is a cornerstone of most international and national policies and guidelines. Non-adherence results in increased length and severity of illness, death, disease transmission, and drug resistance. Treatment interruption is often due to patient-related factors—classed as loss to follow-up (LTFU)—but can also be a result of provider issues, such as stock-outs of medicines. The purpose of this study was to estimate the morbidity, mortality, and economic impact of TB treatment interruption due to stock-outs and LTFU. The results are expected to help promote the benefits of ensuring the availability of good quality medicines and of undertaking interventions to reduce LTFU.

For the research summary, please follow this link.

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Practical Guide for the Quantification of Anti-TB Medicines: Guidelines for Quantification and Supply Planning for Procurement

This guide is intended to serve as a reference for national-level quanitification, forecasting, and supply planning to inform the procurement of anti-TB medicines in the Philippines. It provides practical guidance for program managers, technical staff, and other key personnel, outlining common considerations and best practices for quantification, and highlighting different methods. It also includes specific guidance for the collection, review, and analysis of data, as well as for building forecast assumptions. To aid in completing quantification exercises, this guide also includes instructions for using QuanTB—an electronic quantification and early warning system designed by SIAPS to improve procurement processes, ordering, and supply planning for TB treatment.

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e-TB Manager: Nine country user experience analysis shows positive results

The International Journal of Medical Informatics recently published the results of a user experience analysis that SIAPS led on e-TB Manager, a digital health tool used to manage TB patients. Using quantitative methods, SIAPS staff analyzed user experiences in nine diverse country health systems that cumulatively bear nearly one-third of the world’s TB burden. The study compared […]

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Improving patient safety and building stronger health systems in Georgia

TB patients on second-line treatment experience a significant number of adverse effects. Some TB medicines result in adverse effects that, if not continuously monitored, can become serious and/or permanent and may hinder patient adherence to treatment. A number of other risk factors can also impact the safety of patients taking TB medicines, including drug interactions […]

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Introducing new TB medicines in five countries

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Improving data for decision making: Philippines adopts SIAPS-developed Pharmacovigilance Monitoring System

With the introduction of new anti-tuberculosis (TB) medicines and novel TB treatment regimens in the Philippines, active pharmacovigilance is needed to ensure that both patient safety and the effectiveness of the treatment are monitored. As an important step in pharmacovigilance implementation, the Philippine Department of Health – Pharmaceutical Division (DOH-PD) has adopted the Pharmacovigilance Monitoring […]

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