A multicountry user experience analysis of e-TB Manager and an in-depth study in Ukraine were published. However, the procedural aspects of e-TB Manager implementation in each country were not documented. While facilitators and barriers for eHealth implementation in resource-constrained settings are well known, the objective of this paper is to summarize the tailored implementation approaches given local context, which is a crucial consideration. The paper summarizes the key lessons learned and implications for other electronic health information systems.