Archive A Mengistu

Therapeutics Information and Pharmacovigilance Centre’s Analysis of Spontaneous Adverse Events due to Antiretroviral and Other Medicines

The use of antiretrovirals (ARVs) in combination for treating patients with HIV has greatly ameliorated morbidity and mortality by reducing viral load to undetectable levels and boosting the body’s immunity. However serious adverse reactions causing long- or short-term effects have been associated with ARV treatment. These reactions have caused major concerns internationally, potentially threatening patient … Read more

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Pediatric Antiretroviral Treatment Uptake, Treatment Adherence, Regimen Switches, and Retention in Care in Namibia

In Namibia, a preliminary review of EDT records suggests that children form a small proportion of the patients accessing ART in any given setting, nationally composing 8% of the patients on ART in the MoHSS facilities. Over the years, managing children has been complicated with formulations that have not been friendly for children, complicated regimens, and … Read more

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Sentinel site active surveillance of safety of first-line antiretroviral medicines in Namibia

Mann M, Mengistu A, Gaeseb J, Sagwa E, Mazibuko G, Baeten JM, Babigumira JB, Garrison LP, Stergachis A. Sentinel site active surveillance of safety of first-line antiretroviral medicines in Namibia. Pharmacoepidemiology and Drug Safety. 2016, Vol 25, Issue 9; 1052-1060. Read the full article

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Active Surveillance versus Spontaneous Reporting for First-Line Antiretroviral Medicines in Namibia: A Cost-Utility Analysis

Mann M, Mengistu A, Gaeseb J, Sagwa E, Mazibuko G, Babigumira JB, Garrison Jr LP, Stergachis A. Active surveillance versus spontaneous reporting for first-line antiretroviral medicines in Namibia: A cost-utility analysis. Drug Safety. 2016, Vol. 39, Issue 9; 859-872. Read the full article  

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Sentinel Site Active Surveillance of the Safety of First-Line Antiretroviral Medicines in Windhoek Central Hospital and Katutura Intermediate Hospital

In the Republic of Namibia, the Systems for Improved Access to Pharmaceuticals and Services (SIAPS) program receives funding from the US Government to provide technical guidance for the development and implementation of innovative strategies and programs to strengthen pharmaceutical systems in support of the HIV/AIDS program. SIAPS is collaborating with USAID/Namibia to ensure the availability … Read more

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Strengthening the Nevirapine Safety Signal by Using the Electronic Dispensing Tool in Namibia

The primary objective of this signal strengthening activity was to estimate the frequency of substitution of NVP with a protease inhibitor (PI) during the period 2008 to 2011 and to determine if any increase detected was statistically significant. The incidence of NVP-related reactions of grade 3 and 4 increased with the implementation of Namibia’s 2010 … Read more

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Antimicrobial Sensitivity Patterns of Cerebrospinal Fluid (CSF) Isolates in Namibia: Implications for Empirical Antibiotic Treatment of Meningitis

Mengistu A, Gaeseb J, Uaaka G, Ndjavera C, Kambyambya K, Indongo L, et al. Antimicrobial sensitivity patterns of cerebrospinal fluid (CSF) isolates in Namibia: implications for empirical antibiotic treatment of meningitis. Journal of Pharmaceutical Policy and Practice. 2013;6:4. Read the full article

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