The President’s Malaria Initiative (PMI) is an interagency initiative led by the US Agency for International Development (USAID) with the US Centers for Disease Control and Prevention (CDC). PMI aims to reduce malaria-related mortality by 50% in 15 countries in sub-Saharan Africa by 2010. It plans to meet this goal by achieving 85% coverage of the most vulnerable groups—children under 5, pregnant women, and people living with HIV and AIDS—using proven preventive and therapeutic interventions, including artemisinin-based combination therapies (ACTs), insecticide-treated nets (ITNs), intermittent preventive treatment of malaria in pregnancy (IPTp), and indoor residual spraying (IRS).