Before the implementation of MSH’s Electronic Dispensing Tool, pharmaceutical management and information systems in Ethiopia were poor at capturing, aggregating, and reporting data relevant for informing decision making. This was especially true at service delivery points. With the introduction of Antiretroviral Therapy (ART) in Ethiopia, it became clear that without an effective information system, it would be challenging—if not impossible—to ensure the uninterrupted availability and rational use of the newly acquired ARVs. EDT is a cutting-edge information system that uses the patient as the focal point. EDT captures the critical information needed to make decisions about the individual’s drug regime as well as stock inventory and aggregate patient statistics. USAID-funded SIAPS has partnered with Ethiopia’s Pharmaceuticals Fund and Supply Agency (PFSA) to establish and maintain an effective electronic information system at ART pharmacies to monitor patient adherence; drug resistance; access to medicines; prescribing, dispensing, and medicine use practices; and patient safety.