HIV, malaria, and unintended fertility constitute barriers to the achievement of Millennium Development Goals 4, 5, and 6 in Cameroon. The national health sector strategy 2011-2015 describes disease control targets, including the elimination of mother-to-child HIV transmission and reducing child mortality. In this analysis, SIAPS provides evidence for the design of interventions to strengthen the health supply system—a crucial factor in achieving health targets in Cameroon. Included among these interventions is the national strategy for the prevention of mother-to-child HIV transmission (PMTCT), PMTCT Option B+. This analysis sets out to determine optimal storage space and logistics costs for the rollout of PMTCT Option B+; logistics management information requirements; feasible supply options, labor and equipment requirements, and regulations and policies related to the distribution of PMTCT Option B+ and antiretroviral treatment (ART) commodities.